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- Title
Partial Tolerant State Against H-2 Disparate Cells.
- Authors
Jacobsson, H.; Lilliehook, B.; Blomgren, H.
- Abstract
Injection of CBA mice with H-2-compatible lymphoid cells from C3H hybrids induces a specific reduction of the mixed lymphocyte culture (MLC) response of their lymphocytes. This is not the case after injection of H-2-disparate C3H-hybrid cells, presumably because they are rapidly eliminated due to the immune response of the host. This investigation shows that CBA mice injected with CBA x C57Bl cells (H-2-disparate) at an age of 0-3 days, but not older, develop a specifically reduced MLC response after infusion of C3H X C57Bl cells as adults, indicating that they were tolerant to the C57Bl-determined antigens. However, lymphocytes from such mice showed a normal reactivity against C57Bl as assessed by MLC, graft-versus-host tests, and capacity to produce specific antibodies.
- Subjects
H-2 locus; CELLS; LYMPHOCYTES; IMMUNE response; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1976, Vol 5, Issue 8, p949
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1976.tb03046.x