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- Title
Identification of T Cells that Respond to Serovar-Specific Regions of the Chlamydia trachomatis Major Outer Membrane Protein in Persons with Serovar E Infection.
- Authors
Arno, Janet N.; Xie, Congping; Jones, Robert B.; Van Der Pol, Barbara
- Abstract
Protection from Chlamydia trachomatis infection is serovar-specific and T cell-dependent; however, the T cell epitopes identified to date have not been serovar-specific. The chlamydial major outer membrane protein (MOMP) contains serovar-specific B cell epitopes in four regions of the molecule whose amino acid sequence varies among serovars, the variable segments (VS). Serovar-specific T cell epitopes were sought by examining proliferation of blood mononuclear cells (PBMC) from Chlamydia-infected patients in response to VS peptides of serovar E MOMP. Serovar E—specific peptides from VS1, VS2, and VS4 stimulated PBMC to a greater extent in serovar E—infected than in non-E—infected subjects. Peptides containing constant regions of MOMP were recognized equally by all infected persons. The observed responses were attributable to T cells. T cell recognition of serovar-specific regions of MOMP is common and may contribute to the serovar-specific protection previously observed.
- Publication
Journal of Infectious Diseases, 1998, Vol 178, Issue 6, p1713
- ISSN
0022-1899
- Publication type
Article