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- Title
Pentoxifylline Improves Cell-Mediated Immunity and Reduces Human Immunodeficiency Virus (HIV) Plasma Viremia in Asymptomatic HIV-Seropositive Persons.
- Authors
Clerici, Mario; Piconi, Stefania; Balotta, Claudia; Trabattoni, Daria; Capetti, Amedeo; Fusi, Maria Luisa; Ruzzante, Stefania; Longhi, Renato; Colombo, Maria Chiara; Moroni, Mauro; Milazzo, Francesco
- Abstract
The effects of pentoxifylline on immunologic and virologic parameters were evaluated in 10 human immunodeficiency virus—infected patients not receiving antiretroviral treatment. Patients were asymptomatic, had 300–500 CD4 cells/µL, and received pentoxifylline (1200 mg/day orally) for 4 months. Peripheral blood mononuclear cells were tested before and at five time points during therapy. A transient increase in CD4 cells was observed in 8 of 9 patients, and CD8 cells increased in 7 of 9 patients. These increases were negatively correlated with susceptibility to in vitro mitogen-stimulated apoptotic cell death. Pentoxifylline had a temporary effect on mitogen-stimulated cytokine production; thus, interferon-γ, interleukin (IL)-2, tumor necrosis factor-α, and lymphotoxin increased more than IL-10. Pentoxifylline also potentiated antigen-stimulated IL-2 production and proliferation in 8 of 9 patients and induced significant but transient decreases in plasma viremia in 7 of 9 patients. These preliminary findings suggest that pentoxifylline in vivo has an interesting but temporary influence on both immunologic and virologic parameters.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 5, p1210
- ISSN
0022-1899
- Publication type
Article