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- Title
Induction of Interleukin (IL)-8 Gene Expression by Respiratory Syncytial Virus Involves Activation of Nuclear Factor (NF)-κB and NF-IL-6.
- Authors
Mastronarde, John G.; He, Rei; Monick, Marty M.; Mukaida, Naofumi; Matsushima, Kouji; Hunninghake, Gary W.
- Abstract
Respiratory syncytial virus (RSV) preferentially infects respiratory epithelium and is an important cause of lower respiratory tract infections in young children. RSV induces the production of interleukin (IL)-8 in airway epithelial cells; however, the mechanism of this induction is not known. To define the mechanism by which RSV induces IL-8 gene activation, A549 epithelial cells were transfected with plasmids containing serial deletions of the 5′-flanking region of the IL-8 gene and then exposed to RSV for 24 h. A positive cooperative effect of the binding sites for the transcription factors, nuclear factor (NF)-κB and NF-IL-6, was observed. Mutations in either region abates responsiveness of the promoter to RSV infection. RSV also increases activation of the NF-κB and NF-IL-6 transcription factors. These data suggest that RSV may increase IL-8 production in airway epithelium partly via activation of the transcription factors NF-κB and NF-IL-6.
- Publication
Journal of Infectious Diseases, 1996, Vol 174, Issue 2, p262
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/174.2.262