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- Title
Independent prognostic value of the congestion and renal index in patients with acute heart failure.
- Authors
Run-Qing JI; Bin WANG; Jin-Guo ZHANG; Shu-Hong SU; Li LI; Qin YU; Xian-Yan JIANG; Xin FU; Xue-Hua FANG; Xiao-Wen MA; Ao-Xi TIAN; Jing LI
- Abstract
BACKGROUND: Clinical outcomes are poor if patients with acute heart failure (AHF) are discharged with residual congestion in the presence of renal dysfunction. However, there is no single indication to reflect the combined effects of the two related pathophysiological processes. We, therefore, proposed an indicator, congestion and renal index (CRI), and examined the associations between the CRI and one-year outcomes and the incremental prognostic value of CRI compared with the established scoring systems in a multicenter prospective cohort of AHF. METHODS: We enrolled AHF patients and calculated the ratio of thoracic fluid content index divided by estimated glomerular filtration rate before discharge, as CRI. Then we examined the associations between CRI and one-year outcomes. RESULTS: A total of 944 patients were included in the analysis (mean age 63.3 ± 13.8 years, 39.3% women). Compared with patients with CRI ≤ 0.59 mL/min per kΩ, those with CRI > 0.59 mL/min per kΩ had higher risks of cardiovascular death or HF hospitalization (HR = 1.56 [1.13-2.15]) and all-cause death or all-cause hospitalization (HR = 1.33 [1.01-1.74]). CRI had an incremental prognostic value compared with the established scoring system. CONCLUSIONS: In patients with AHF, CRI is independently associated with the risk of death or hospitalization within one year, and improves the risk stratification of the established risk models.
- Subjects
CHINA; BODY fluid analysis; BIOMARKERS; GLOMERULAR filtration rate; CHEST (Anatomy); CAUSES of death; RESEARCH; KIDNEYS; CONFIDENCE intervals; VENTRICULAR ejection fraction; CROSS-sectional method; INTERVIEWING; MANN Whitney U Test; BODY surface area; COMPARATIVE studies; HOSPITAL care of older people; RESEARCH funding; DESCRIPTIVE statistics; CARDIOGRAPHY; QUESTIONNAIRES; CHI-squared test; BLOOD testing; LOGISTIC regression analysis; PEPTIDE hormones; ACUTE diseases; HEART failure; LONGITUDINAL method; DISCHARGE planning; PROPORTIONAL hazards models
- Publication
Journal of Geriatric Cardiology, 2023, Vol 20, Issue 7, p516
- ISSN
1671-5411
- Publication type
Article
- DOI
10.26599/1671-5411.2023.07.006