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- Title
MICA polymorphism is associated with type 1 diabetes in the Korean population.
- Authors
Park, Yongsoo; Lee, Hongkyu; Sanjeevi, Carani B.; Eisenbarth, George S.; Park, Y; Lee, H; Sanjeevi, C B; Eisenbarth, G S
- Abstract
<bold>Objective: </bold>Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Koreans.<bold>Research Design and Methods: </bold>A total of 119 patients selected from Korean Seoul type 1 diabetes registry and 134 nondiabetic unrelated control subjects were typed for exon 5 polymorphism of MICA in addition to HLA DR-DQ typing. A total of 52 simplex families of type 1 diabetes were also studied.<bold>Results: </bold>The MICA microsatellite allele consisting of six repetitions of GCT/AGC (A6) was present at a significantly lower frequency in the diabetic patient group (Pc < 0.01; Pc = P value after Bonferroni correction) than in the control population. The MICA microsatellite allele consisting of four repetitions (A4) was present at a higher frequency in diabetic patients (P < 0.05). This deviated distribution was not changed even after controlling for the HLA DRB1-DQB1 haplotype. Transmission/disequilibrium test revealed significant deviation of transmission for alleles at the A6 polymorphism within the MICA gene (P < 0.05).<bold>Conclusions: </bold>We could assess that the MICA gene might be associated with type 1 diabetes transracially independent of the HLA gene.
- Subjects
MAJOR histocompatibility complex; GENETICS of diabetes; KOREANS; DISEASES
- Publication
Diabetes Care, 2001, Vol 24, Issue 1, p33
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.24.1.33