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- Title
Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study.
- Authors
Muggeo, M; Zoppini, G; Bonora, E; Brun, E; Bonadonna, R C; Moghetti, P; Verlato, G
- Abstract
<bold>Objective: </bold>In the present study, we evaluated whether the coefficient of variation (CV) of fasting plasma glucose (FPG) over a 3-year period was a significant predictor of mortality in type 2 diabetic patients aged 56-74 years.<bold>Research Design and Methods: </bold>All type 2 diabetic patients (n = 1,409) aged 56-74 years attending the Verona Diabetes Clinic and having at least two FPG determinations in each of the years 1984-1986 were followed for 10 years (1987-1996) to assess total and cause-specific mortality Patients were grouped into tertiles of mean and CV of FPG during 1984-1986. These parameters as well as sex, age, diabetes duration, insulin treatment, smoking, hypertension, and hypercholesterolemia were included in multivariate survival analyses.<bold>Results: </bold>During the follow-up, 468 patients died. The CV of FPG was an independent predictor of total, cardiovascular, and cancer mortality. Mean FPG was a predictor of total mortality only when the CV of FPG was not included in the analyses.<bold>Conclusions: </bold>Long-term variability of fasting glucose is an independent predictor of mortality in patients with type 2 diabetes. The CV of FPG might be considered a useful additional parameter in the management of these patients.
- Publication
Diabetes Care, 2000, Vol 23, Issue 1, p45
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.23.1.45