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- Title
Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.
- Authors
Bonora, Enzo; Targher, Giovanni; Alberiche, Maria; Bonadonna, Riccardo C.; Saggiani, Francesca; Zenere, Marina B.; Monauni, Tiziano; Muggeo, Michele; Bonora, E; Targher, G; Alberiche, M; Bonadonna, R C; Saggiani, F; Zenere, M B; Monauni, T; Muggeo, M
- Abstract
<bold>Objective: </bold>To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.<bold>Research Design and Methods: </bold>In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity.<bold>Results: </bold>We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P<0.0001), with no substantial differences between men (r = -0.800) and women (r = -0.796), younger (aged <50 years, r = -0.832) and older (r = -0.800) subjects, nonobese (BMI <27 kg/m2, r = -0.800) and obese (r = -0.765) subjects, nondiabetic (r = -0.754) and diabetic (r = -0.695) subjects, and normotensive ( r = -0.786) and hypertensive (r = -0.762) subjects. Also, we found good agreement between the two methods in the categorization of subjects according to insulin sensitivity (weighted k = 0.63).<bold>Conclusions: </bold>We conclude that the HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity
- Subjects
HOMEOSTASIS; INSULIN; TYPE 2 diabetes; GLUCOSE; BLOOD; CARBOHYDRATE intolerance; GLUCOSE metabolism; AGE distribution; BIOLOGICAL models; BLOOD sugar; COMPARATIVE studies; HUMAN reproduction; HYPERINSULINISM; INTRAVENOUS therapy; RESEARCH methodology; MEDICAL cooperation; REFERENCE values; REGRESSION analysis; RESEARCH; EVALUATION research; GLUCOSE clamp technique
- Publication
Diabetes Care, 2000, Vol 23, Issue 1, p57
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.23.1.57