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- Title
Incidence and significance of islet cell antibodies in women with previous gestational diabetes.
- Authors
Catalano, Patrick M.; Tyzbir, Elaine D.; Sims, Ethan A. H.; Catalano, P M; Tyzbir, E D; Sims, E A
- Abstract
Islet cell antibodies (ICAs) are markers for patients at risk for insulin-dependent diabetes and are associated with progressive beta-cell destruction. This prospective study was performed to estimate the incidence of these antibodies in 187 women with previous gestational diabetes. With a specific protein A monoclonal antibody (MoAb) assay, the incidence of ICAs was only 1.6% (3 of 187). Oral and intravenous glucose tolerance tests were performed in these 3 women and compared with 6 women with previous gestational diabetes without ICAs and 5 control women. Glucose tolerance was impaired only in the 3 women with ICAs, who also had an increase (P less than 0.03) in fasting plasma glucose and a decrease (P less than 0.03) in early first-phase insulin response. We conclude that the more specific MoAb method indicates a lower incidence of ICA in women with a history of gestational diabetes than previously reported and that a decreased first-phase insulin response is associated with the presence of ICAs, suggesting progressive islet cell damage.
- Publication
Diabetes Care, 1990, Vol 13, Issue 5, p478
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.13.5.478