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- Title
Lung Tissue Transcriptomics Reveal Associations between Thymic Stromal Lymphopoietin Signaling, Mast Cells, and Airway Obstruction in Active Smokers.
- Authors
Milad, Nadia; Aubin, Sophie; Racine, Christine; Maltais, François; Bossé, Yohan; Morissette, Mathieu C.
- Abstract
This letter discusses a study that investigated the associations between thymic stromal lymphopoietin (TSLP) signaling, mast cells, and airway obstruction in active smokers. The study used lung tissue transcriptomics and clinical data from 213 active smokers to analyze the levels of TSLP and CRLF2 transcripts in relation to clinical features and predicted immune cell signatures. The results showed that high levels of CRLF2 transcripts were associated with lower lung function in female subjects, and both male and female subjects with high CRLF2 transcript levels had fewer M2 macrophages and more activated mast cells and neutrophils. The study suggests that further investigation is needed to understand the mechanistic link between COPD progression, TSLP signaling, and activated mast cell abundance in smokers.
- Subjects
LUNGS; THYMIC stromal lymphopoietin; MAST cells; RESPIRATORY obstructions; TRANSCRIPTOMES; ADRENERGIC beta agonists
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2024, Vol 71, Issue 1, p10
- ISSN
1044-1549
- Publication type
Letter
- DOI
10.1165/rcmb.2023-0416LE