We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effect of haloperidol's perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis.
- Authors
Liu, Meinv; Su, Jie; Wang, Bei; Yu, Dongdong; Li, Jianli; Cao, Xinyu
- Abstract
Objectives: To systematically review the evidence about the effect of haloperidol on postoperative delirium in elderly patients. Methods: PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure were used to find concerned studies for meta-analysis. The main outcome was the incidence of postoperative delirium, and the secondary outcomes were side effects of haloperidol and the length of hospital stay. The meta-analyses were conducted using the Review Manager Version 5.1. This study was conducted based on the PRISMA statement. Results: Eight RCTs (1569 patients) were included in the meta-analysis. There was a significant difference in the incidence of postoperative delirium between haloperidol and control groups (OR = 0.62, 95%CI 0.48–0.80, P = 0.0002, I2 = 20%). In addition, side effects of haloperidol and the duration of hospitalization were comparable (OR = 0.58, 95%CI 0.25–1.35, P = 0.21, I2 = 0%; MD =-0.01, 95%CI -0.16-0.15, P = 0.92, I2 = 28%). Subgroup analysis implied the effect of haloperidol on postoperative delirium might vary with the dose (5 mg daily: OR = 0.40, 95%CI 0.22–0.71, P = 0.002, I2 = 0%; <5 mg daily: OR = 0.72, 95%CI 0.42–1.23, P = 0.23, I2 = 0%). Conclusions: The meta-analysis revealed perioperative application of haloperidol could decrease the occurrence of postoperative delirium without obvious side effects in elderly people, and high-dose haloperidol (5 mg daily) possessed a greater positive effect.
- Subjects
DRUG efficacy; ONLINE information services; MEDICAL databases; LENGTH of stay in hospitals; META-analysis; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; SYSTEMATIC reviews; HALOPERIDOL; POSTOPERATIVE period; DELIRIUM; DESCRIPTIVE statistics; MEDLINE; DATA analysis software; ODDS ratio; EVALUATION; OLD age
- Publication
BMC Anesthesiology, 2024, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-024-02434-8