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- Title
Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet.
- Authors
Wang, Yang; Xie, Bing-Qing; Gao, Wei-Hua; Yan, Ding-Yi; Zheng, Wen-Ling; Lv, Yong-Bo; Cao, Yu-Meng; Hu, Jia-Wen; Yuan, Zu-Yi; Mu, Jian-Jun
- Abstract
Background/Aims: The aim of our study was to investigate the effect of high-salt diet on the renal expression of renalase and the potential role of the local renin-angiotensin system in this process. Methods: Sprague-Dawley (SD) rats were divided into groups according to salt content in diet and drug treatment as follows: normal-salt diet (NS), high-salt diet (HS), high-salt intake with hydralazine (HS+H), high-salt diet with enalapril (HS+E), and high-salt diet with valsartan (HS+V). The dietary intervention and drugs were given for four weeks. Renin activity and angiotensin II type 1 receptor (AT1R) levels were detected by real-time PCR. Renalase mRNA and protein were also measured. Results: After four weeks, systolic blood pressure and proteinuria were significantly increased in the HS group with respect to the NS group. Dietary salt intake caused a dramatic decrease in renalase expression in the rat kidneys. Renal cortex renin and AT1R increased significantly in the HS and HS+H groups. Urinary protein was positively correlated with renal renin and AT1R levels. However, in the HS+E and HS+V groups, enalapril and valsartan failed to influence renal renalase expression but abolished the increase in proteinuria, renal cortex renin, and AT1R levels with respect to the HS group. Conclusion: This study indicates that high salt intake reduces renal expression, and renal RAS may be not involved in the regulation of renalase in SD rats fed with high-salt diet.
- Subjects
RENIN-angiotensin system; PROTEINURIA; LABORATORY rats; HIGH-salt diet; ENALAPRIL; SYSTOLIC blood pressure; VALSARTAN
- Publication
Kidney & Blood Pressure Research, 2015, Vol 40, Issue 6, p605
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000368536