We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Establishment of methylation patterns in ES cells.
- Authors
Sabag, Ofra; Zamir, Ayelet; Keshet, Ilana; Hecht, Merav; Ludwig, Guy; Tabib, Amalia; Moss, Joshua; Cedar, Howard
- Abstract
After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.
- Subjects
EUKARYOTIC cells; DNA methylation; GLYCOSYLATION; SOMATIC cells; EMBRYONIC stem cells; LABORATORY mice
- Publication
Nature Structural & Molecular Biology, 2014, Vol 21, Issue 1, p110
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2734