The article discusses the study "Nuclear architecture Dictates HIV-1 Integration site selection," researcher B. Marini and colleagues and published in the journal "Nature." It is stated that the study depict how integration of viral cDNA into the genome of host cells is strongly associated with the three-dimensional (3D) architecture of chromatin. The study revealed the role of nuclear pore complex (NPC)-proximal regions in productive HIV-1 gene expression.