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- Title
Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?
- Authors
Da Yeon Oh; Ji Won Kim; Seong-Joon Koh; Mingoo Kim; Ji Hoon Park; Su Yeon Cho; Byeong Gwan Kim; Kook Lae Lee; Jong Pil Im
- Abstract
Background/Aims: Hyperglycemia is associated with decreased 2-18[F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumors assessed by positron emission tomography (PET). In this retrospective study we investigated a comparison of standardized uptake values (SUVs) in patients with primary colorectal cancers who either had diabetes mellitus (DM) or were otherwise healthy. Methods: The medical records of 397 patients who were diagnosed with colorectal cancer and underwent PETCT between January 2006 and December 2012 were analyzed. Eighty patients with DM and 317 patients without DM were included. Clinical characteristics were reviewed and maximal standardized uptake values (SUVmax) were calculated in the primary colorectal lesions. Results: There was no significant difference between tumor SUVmax in DM patients (10.60±5.78) and those without DM (10.92±5.44). In addition, no significant difference was detected between tumor SUVmax in DM patients with glycated hemoglobin (HbA1c) levels <8% (10.34±5.17) and those with HbA1c levels ≥8% (10.61±7.27). The maximum size of the primary colorectal tumor was associated with SUVmax in a linear regression analysis. Conclusion: The results of this study showed that DM did not influence FDG uptake values in colorectal cancer patients regardless of glucose levels.
- Subjects
DIABETES; POSITRON emission tomography; COLON cancer; GLYCOSYLATED hemoglobin; GLUCOSE in the body; RETROSPECTIVE studies
- Publication
Intestinal Research, 2014, Vol 12, Issue 2, p146
- ISSN
1598-9100
- Publication type
Article
- DOI
10.5217/ir.2014.12.2.146