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- Title
Oral Sulfate Solution and Polyethylene Glycol with Ascorbic Acid in a Split Method for Bowel Preparation in Patients with Ulcerative Colitis: Preliminary Data.
- Authors
Ji Min Lee; Kang-moon Lee; Dae Bum Kim; Ik Hyun Jo
- Abstract
Background/Aims Low-volume preparations are gaining attention for higher acceptability. Oral sulfate solution (OSS) for preparation may cause symptom flares in patients with ulcerative colitis (UC), little is known in this population. We compare the efficacy, safety, tolerability and acceptability of OSS and 2-L polyethylene glycol with ascorbic acid (PEG-Asc) in a split method for bowel preparation in patients with UC. Methods This was a multicenter, randomized, and single-blind study. Adult outpatients with UC who had stable disease activity (n=110) were randomly allocated to OSS or 2-L PEG-Asc for undergoing colonoscopy. Bowel cleansing was assessed using the Boston Bowel Preparation Scale and rated as successful cleansing if the score was ≥6. Patient acceptance (ease of administration and willingness to repeat), compliance (amount of intake), and tolerability (newly developed symptoms such as nausea, bloating, and abdominal pain) were asked with 4-point ordinal scale. Disease activity (partial Mayo/Mayo score) and laboratory data before and after colonoscopy were also checked for safety issue. Results After exclusions, 53 subjects in the OSS group and 53 subjects in the PEG-Asc group completed the study and were analyzed. There was no significant difference in successful cleansing: 96.2% in the OSS group versus 98.1% in the PEG-Asc group (p=0.5). The acceptance, compliance, and tolerability were not significantly different between two groups (all p>0.05). There was no significant change in serum electrolytes and disease activity in either group. Conclusions OSS is effective at colonoscopy cleansing and has acceptable tolerability when it is compared with PEG-Asc. Also, OSS does not affect disease activity so that OSS could be used safe for bowel preparation in patients with UC.
- Subjects
ULCERATIVE colitis; POLYETHYLENE glycol; VITAMIN C; BOWEL preparation (Procedure); SULFATES; ABDOMINAL pain
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p164
- ISSN
1976-2283
- Publication type
Article