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- Title
Frontispiece: 4,5-Dihydro-1,2,3-oxadiazole: A Very Elusive Key Intermediate in Various Important Chemical Transformations.
- Authors
Banert, Klaus; Singh, Neeraj; Fiedler, Benjamin; Friedrich, Joachim; Korb, Marcus; Lang, Heinrich
- Abstract
Reactive Intermediates. The very weak NO bond of 4,5 ‐ dihydro ‐ 1,2,3 ‐ oxadiazole is most probably responsible for the elusive properties of this heterocycle. Thus, it cannot be directly detected even by low ‐ temperature NMR monitoring. However, the formation of the secondary products ethylene oxide, acetaldehyde, and diazomethane is strong evidence for the generation of the five ‐ membered heterocycle, as reported by K. Banert, J. Friedrich et al. in their Communication on page 15092 ff. The parent compound and bicyclic 4,5 ‐ dihydro ‐ 1,2,3 ‐ oxadiazoles are discussed as short ‐ lived intermediates in medicinal chemistry and industrial processes, respectively.
- Subjects
CHEMICAL amplification; NITROSOUREAS
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 43, pn/a
- ISSN
0947-6539
- Publication type
Other
- DOI
10.1002/chem.201584361