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- Title
MicroRNA-191 regulates differentiation and migration of mesenchymal stem cells and their paracrine effect on angiogenesis.
- Authors
Liu, Yuanxing; Liu, Xi; Ye, Pengxiang; Zhang, Xiafei; Schilling, Arndt F.; Yonezawa, Tomo; Gao, Guifang; Cui, Xiaofeng
- Abstract
MicroRNAs (miRNAs) are critical regulators in organ development. Among them, miR-191 is known to be regulated in early embryogenesis and dysregulated in cancer. This role in undifferentiated tissues suggests a possible part of miR-191 also in bone marrow derived mesenchymal stem cells (BMSCs) physiology. Here, we report that miR-191 decreased MMP expression and migration of BMSCs. Conditioned media of miR-191 overexpressing BMSCs block VEGF expression, and inhibit angiogenesis of HUVECs. Under osteogenic culture conditions, inhibition of miR-191 significantly induces bone formation. Moreover, our studies showed miR-191 might influence chondrogenesis of BMSCs by directly targeting CCAAT Enhancer Binding Protein Beta (CEBPB). Taken together, here we demonstrate the role of miR-191 in differentiation, migration and paracrine function of BMSCs.
- Subjects
MESENCHYMAL stem cell differentiation; MESENCHYMAL stem cells; MORPHOGENESIS; PARACRINE mechanisms; BONE growth
- Publication
Biotechnology Letters, 2020, Vol 42, Issue 9, p1777
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-020-02907-z