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- Title
Aeration and fermentation strategies on nisin production.
- Authors
Jiang, Liyan; Liu, Yan; Yan, Guodong; Cui, Yuxiao; Cheng, Qiyue; Zhang, Zaixiao; Meng, Qingfan; Teng, Lirong; Ren, Xiaodong
- Abstract
Objectives: To optimize nisin production in Lactococcus lactis by using different aeration and fermentation strategies. Results: The nisin titer and specific nisin production rate reached maximum values of 11,900 IU/ml and 4110 IU/g/h, respectively, in aerobic batch fermentation with glucose as C source. These values were higher than in anaerobic batch fermentation (10,700 IU/ml and 3260 IU/g/h, respectively). The maximum specific nisin production rates appeared earlier in aerobic batch fermentation, which suggests that nisin production is stimulated by aeration. Different fermentation strategies were compared: maximum nisin production (15,400 IU/ml) was achieved with fed-batch fermentation with a variable rate of feeding under aerobic conditions. Conclusion: Nisin production can be stimulated by aeration, which goes against the typical conditions involving strict anaerobiosis.
- Subjects
BIOTECHNOLOGY research; NISIN; LACTOCOCCUS lactis; FERMENTATION; GLUCOSE
- Publication
Biotechnology Letters, 2015, Vol 37, Issue 10, p2039
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-015-1886-1