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- Title
Perfusion and apparent oxygenation in the human placenta (PERFOX).
- Authors
Hutter, Jana; Harteveld, Anita A.; Jackson, Laurence H.; Franklin, Suzanne; Bos, Clemens; Osch, Matthias J. P.; O'Muircheartaigh, Jonathan; Ho, Alison; Chappell, Lucy; Hajnal, Joseph V.; Rutherford, Mary; De Vita, Enrico
- Abstract
Purpose: To study placental function—both perfusion and an oxygenation surrogate (T2*)—simultaneously and quantitatively in‐vivo. Methods: Fifteen pregnant women were scanned on a 3T MR scanner. For perfusion measurements, a velocity selective arterial spin labeling preparation module was placed before a multi‐echo gradient echo EPI readout to integrate T2* and perfusion measurements in 1 joint perfusion‐oxygenation (PERFOX) acquisition. Joint motion correction and quantification were performed to evaluate changes in T2* and perfusion over GA. Results: The optimized integrated PERFOX protocol and post‐processing allowed successful visualization and quantification of perfusion and T2* in all subjects. Areas of high T2* and high perfusion appear to correspond to placental sub‐units and show a systematic offset in location along the maternal‐fetal axis. The areas of highest perfusion are consistently closer to the maternal basal plate and the areas of highest T2* closer to the fetal chorionic plate. Quantitative results show a strong negative correlation of gestational age with T2* and weak negative correlation with perfusion. Conclusions: A strength of the joint sequence is that it provides truly simultaneous and co‐registered estimates of local T2* and perfusion, however, to achieve this, the time per slice is prolonged compared to a perfusion only scan which can potentially limit coverage. The achieved interlocking can be particularly useful when quantifying transient physiological effects such as uterine contractions. PERFOX opens a new avenue to elucidate the relationship between maternal supply and oxygen uptake, both of which are central to placental function and dysfunction.
- Subjects
PERFUSION; SPIN labels; UTERINE contraction; PLACENTA; PREGNANT women
- Publication
Magnetic Resonance in Medicine, 2020, Vol 83, Issue 2, p549
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.27950