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- Title
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleoside.
- Authors
Okoth, Dorothy A.; Hug, Joachim J.; Garcia, Ronald; Spröer, Cathrin; Overmann, Jörg; Müller, Rolf
- Abstract
Myxobacteria represent an under-investigated source for biologically active natural products featuring intriguing structural moieties with potential applications, e.g., in the pharmaceutical industry. Sorangiadenosine and the here-discovered 2-hydroxysorangiadenosine are myxobacterial sesquiterpene–nucleosides with an unusual structural moiety, a bicyclic eudesmane-type sesquiterpene. As the biosynthesis of these rare terpene–nucleoside hybrid natural products remains elusive, we investigated secondary metabolomes and genomes of several 2-hydroxysorangiadenosine-producing myxobacteria. We report the isolation and full structure elucidation of 2-hydroxysorangiadenosine and its cytotoxic and antibiotic activities and propose a biosynthetic pathway in the myxobacterium Vitiosangium cumulatum MCy10943T.
- Subjects
ANTINEOPLASTIC antibiotics; BIOSYNTHESIS; NATURAL products; NUCLEOSIDE synthesis; MYXOBACTERALES; METABOLOMICS; METABOLITES
- Publication
Molecules, 2020, Vol 25, Issue 11, p2676
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25112676