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- Title
When Clinical Trial Participation Is Not an Option in the Era of Personalized Medicine: The Case of Two Patients.
- Authors
Verschraegen, Claire F.; Rehman, Hibba; Pulluri, Bhargavi; DeKay, James; Barry, Maura; Folefac, Edmund; Dittus, Kim; Holmes, Chris; Sprague, Julian; Ades, Steve; Gibson, Pam C.
- Abstract
The combination of personalized therapy with immunotherapy might lead to rapid complete remission in patients who are too sick to be eligible for clinical trials. We report 2 such extraordinary responders. A discussion on the use and purpose of clinical trials in this new era of very active anticancer drug discovery concludes that a paradigm shift is urgently needed.
- Subjects
MELANOMA diagnosis; LIVER failure; ANAPLASTIC thyroid cancer; ANTINEOPLASTIC agents; CLINICAL trials; COMPUTED tomography; DRUG design; IMMUNOTHERAPY; LIVER tumors; LUNG tumors; METASTASIS; PHARYNGITIS; DISEASE relapse; DISEASE remission; INDIVIDUALIZED medicine; PHARMACODYNAMICS; DIAGNOSIS
- Publication
Oncology, 2017, Vol 92, Issue 1, p55
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000450712