We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers.
- Authors
Chia, H. Y.; Tey, H. L.; Tan, K. B.; Chong, W. S.
- Abstract
Primary cutaneous T-cell lymphomas are rare and can be difficult to classify precisely. We present a case of extranodal natural killer (NK)/T-cell lymphoma in a previously healthy, immunocompetent man who presented with extensive necrotic leg ulcers and disseminated skin nodules. Immunohistochemical studies revealed that the tumour cells were positive for CD3, CD30, granzyme B and T-cell intracellular antigen-1, and negative for CD5 and CD56, with positive staining for Epstein–Barr virus (EBV) RNA on in situ hybridization. A diagnosis of extranodal NK/T-cell lymphoma was made, based on the presence of cytotoxic granules and positive EBV RNA staining. The patient was treated with a regimen of chemotherapy comprising corticosteroids, intravenous methotrexate, ifosphamide, L-asparginase and etoposide with initial response.
- Subjects
T-cell lymphoma; LEG diseases; KILLER cells; NODULAR disease; CELL tumors; DIAGNOSTIC use of in-situ hybridization; EPSTEIN-Barr virus; DRUG therapy
- Publication
Clinical & Experimental Dermatology, 2009, Vol 34, Issue 8, pe693
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2009.03428.x