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- Title
Salvage Chemotherapy with Docetaxel and Epirubicin for Advanced/Metastatic Gastric Cancer.
- Authors
Jae Yun Lim; Jae Yong Cho; Yong Han Paik; Dong Ki Lee; Sang In Lee; Hyo Jin Park; Se Joon Lee; Kwan Sik Lee; Dong Sup Yoon; Seung Ho Choi
- Abstract
Background: We conducted a phase II study to assess the efficacy and tolerability of docetaxel and epirubicin as salvage chemotherapy in advanced/metastatic gastric cancer patients with documented progression after 5-fluorouracil/platinum-based combination chemotherapy. Methods: Docetaxel 75 mg/m2 and epirubicin 50 mg/m2 were administered on days 1 and 2, respectively, every 3 weeks. Treatment continued until progression of disease or until a life-threatening adverse event occurred. The primary objectives of this study were to evaluate the safety profile and response rate to this treatment regimen. Results: Thirty-four patients were enrolled in the study. Twenty-six patients had locally advanced or metastatic disease at the time of diagnosis, and 8 patients had recurrent disease after surgical resection of the primary tumor. A total of 157 chemotherapy cycles were administered. Seven (21.8%) patients had a partial response and 12 (37.5%) patients had stable disease. The median time to progression and overall survival were 4.1 and 13.4 months, respectively. Grade III/IV hematologic toxicities included neutropenia in 16 patients (47%) and febrile neutropenia in 8 patients (24%). Nonhematologic toxicities were rare. Conclusion: A combination of chemotherapy with docetaxel and epirubicin showed moderate activity as salvage treatment in advanced/metastatic gastric cancer, especially in patients who had responded to prior chemotherapy. Copyright © 2008 S. Karger AG, Basel
- Subjects
DRUG therapy; DOCETAXEL; GASTROINTESTINAL diseases; CANCER chemotherapy; CANCER treatment
- Publication
Oncology, 2007, Vol 73, Issue 1/2, p2
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000120027