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- Title
Inhibition of Superoxide Dismutase from Ascaris suum by Benzimidazoles and Synthesized Pyrimidine and Glycine Derivatives.
- Authors
Sanchez-Moreno, M.; Entrala, E.; Janssen, D.; Fernandez-Becerra, C.; Salas-Peregrin, J.M.; Osuna, A.
- Abstract
Copper-zinc superoxide dismutase was purified from Ascαris suum (Nematoda). Four benzimidazole derivatives, six recently synthesized pyrimidine derivatives and eleven recently synthesized glycine derivatives were shown to inhibit: (1) purified extracts of A. suum superoxide dismutase; (2) superoxide dismutase from host liver, and (3) purified extracts of superoxide dismutase from living A. suum incubated in the presence of these drugs. Thiabendazole compounds, with a documented effect against helminth parasites, were found to affect the superoxide dismutase. The inhibitory effects of some pyrimidine and glycine derivatives were higher than those of benzimidazoles, and the pyrimidine compounds failed to inhibit the host's enzyme. These derivatives are candidate anthelmintics, acting as inhibitors of certain metalloenzymes in parasites. Copyright © 1996 S. Karger AG, Basel
- Publication
Pharmacology, 1996, Vol 52, Issue 1, p61
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000139362