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- Title
Atenolol-Induced Regulation of Leukocyte β<sub>2</sub>-Adrenoceptors in Hypertension.
- Authors
Piantanelli, L.; Giunta, S.; Basso, A.; Cognini, G.; Andreoni, A.; Paciaroni, E.
- Abstract
β2-Adrenoceptor characteristics of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 100 mg/day atenolol. While no changes have been observed in receptor affinity, a statistically significant increase (36%) has been demonstrated in receptor density following treatment. Blood pressure and heart rate were also measured in order to test the efficacy of the administered drug. All these parameters showed a fall in the post-treatment values. It is concluded that at therapeutic concentration, β2-adrenoceptors undergo up-regulation by atenolol in spite of its cardioselectivity. Such a regulation, which may represent a fundamental step in the mechanism leading to withdrawal syndrome, may, therefore, be suggested being quite widespread. Copyright © 1984 S. Karger AG, Basel
- Publication
Pharmacology, 1984, Vol 29, Issue 4, p210
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000138015