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- Title
Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata.
- Authors
Anuset, Delphine; Perceau, Geraldine; Bernard, Philippe; Reguiai, Ziad
- Abstract
<bold>Background: </bold>In severe alopecia areata (AA), spontaneous recovery is unlikely, and treatment is not standardized.<bold>Objective: </bold>To evaluate the efficacy and safety of methotrexate (MTX) used alone or combined with low- to moderate-dose oral corticosteroids (OC) for treating severe AA (totalis, universalis and severe multifocal).<bold>Methods: </bold>Retrospective monocentric study of all consecutive patients receiving this treatment between 2006 and 2012. Efficacy was defined as achieving a total regrowth of terminal hair.<bold>Results: </bold>26 patients were included (17 with AA universalis or totalis and 9 with severe multifocal AA). Total regrowth was noted in 15/26 patients. After 3 months of treatment, hair regrowth >80% was associated with further complete regrowth, and hair regrowth <30% was associated with later treatment failure (p = 0.0014). When treatment was tapered, 11/15 patients with initial complete efficacy experienced AA relapse.<bold>Conclusion: </bold>MTX combined with low- to moderate-dose OC may be an efficient and well-tolerated treatment for severe AA. However, long-term maintenance treatment is usually required.
- Subjects
ALOPECIA areata; ANTI-inflammatory agents; BALDNESS; COMBINATION drug therapy; CLINICAL trials; DERMATOLOGIC agents; METHOTREXATE; PREDNISONE; REOPERATION; RETROSPECTIVE studies; SEVERITY of illness index; THERAPEUTICS
- Publication
Dermatology (10188665), 2016, Vol 232, Issue 2, p242
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000441250