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- Title
Impact of Coagulation Factors on the Properties of Fibrin Adsorption Films.
- Authors
Milyaeva, O. Yu.; Rafikova, A. R.
- Abstract
The formation of a fibrin film at the sites of cuts and wounds is a complex biochemical process that involves fibrinogen and thrombin as the main components, as well as other enzymes and proteins. Dynamic surface properties of adsorption films obtained from the solution, which contains factors VIII, XIIIa, von Willebrand factor and fibronectin, differ from the fibrinogen adsorption films and fibrin films obtained from a solution containing only fibrinogen and thrombin. Their dynamic surface elasticities exceed the corresponding values for fibrinogen (80 and 55 mN/m, respectively); however, they appear to be lower than value for fibrin prepared from pure components (115 mN/m). The surface pressures achieved for the adsorption films obtained from hemostatic glue (27 mN/m) exceed those for both aforementioned systems (14 mN/m). As follows from the Brewster angle microscopy and scanning electron microscopy data, significant changes in the morphology of the resulting films are responsible for the observed effect.
- Subjects
FIBRIN; BLOOD coagulation factors; BLOOD coagulation factor VIII; VON Willebrand factor; BREWSTER'S angle; FIBRONECTINS; FIBRINOGEN
- Publication
Colloid Journal, 2024, Vol 86, Issue 2, p258
- ISSN
1061-933X
- Publication type
Article
- DOI
10.1134/S1061933X24600052