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- Title
A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles.
- Authors
Weon-Young Son; Jin-Tae Chung; Ri-Cheng Chian; Belen Herrero; Ezgi Demirtas; Shai Elizur; Yariv Gidoni; Camille Sylvestre; Nicola Dean; Seang Lin Tan; Son, Weon-Young; Chung, Jin-Tae; Chian, Ri-Cheng; Herrero, Belen; Demirtas, Ezgi; Elizur, Shai; Gidoni, Yariv; Sylvestre, Camille; Dean, Nicola; Tan, Seang Lin
- Abstract
<bold>Background: </bold>Our aim was to evaluate whether extending the interval between human chorionic gonadotrophin (hCG) priming and immature oocyte retrieval increases the oocyte maturation rate following in vitro maturation (IVM).<bold>Methods: </bold>This study was performed retrospectively. IVM was performed on 113 polycystic ovary syndrome patients (n = 120 cycles). Oocyte collection was performed either 35 h (Group 1; n = 76) or 38 h (Group 2; n = 44) after 10,000 IU of hCG priming. Following oocyte retrieval, oocyte maturity was assessed and the remaining immature oocytes were cultured in IVM medium up to Day 2.<bold>Results: </bold>The number of in vivo matured oocytes collected was significantly higher in Group 2 (13.6%, 114/840 versus 7.3%, 96/1312 in Group 1) (P < 0.01); the oocyte maturation rate after Day 1 was significantly higher (P < 0.01) in Group 2 (46.3 versus 36.0% in Group 1); and clinical pregnancy (40.9 versus 25%) and implantation rates (15.6 versus 9.6%) were better in Group 2 than those in Group 1.<bold>Conclusions: </bold>The results suggest that extending the period of hCG priming time from 35 to 38 h for immature oocyte retrieval promotes oocyte maturation in vivo and increases the IVM rate of immature oocytes. Therefore, oocyte retrieval after 38 h of hCG priming may improve subsequent pregnancy outcome in cycles programmed for IVM treatment.
- Subjects
PREGNANCY; CYCLES; OBSTETRICS; CONCEPTION
- Publication
Human Reproduction, 2008, Vol 23, Issue 9, p2010
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/den210