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- Title
GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial.
- Authors
Lai-Ping Cheung; Po-Mui Lam; Ingrid Hung Lok; Tony Tak-Yu Chiu; Sum-Yee Yeung; Ching-Ching Tjer; Christopher John Haines
- Abstract
BACKGROUND. This is the first published report of a prospective, randomized, controlled trial comparing a fixed, multi-dose GnRH antagonist protocol with a long GnRH agonist protocol in poor responders undergoing IVF. METHODS. Sixty-six poor responders were randomized into two groups: the study group received 0.25?mg of cetrorelix daily starting on day 6 of stimulation; the control group received 600?g of buserelin acetate daily starting in the mid-luteal phase of the preceding cycle. Both groups were given a fixed dose of recombinant FSH (300?IU daily) for stimulation. RESULTS. There were no significant differences in the cycle cancellation rates, duration of stimulation, consumption of gonadotrophins, and mean numbers of mature follicles, oocytes and embryos obtained. The implantation rates were similar, but the number of embryos transferred was significantly higher for the antagonist group (2.320.58 versus 1.500.83; P=0.01). The pregnancy rates were also higher in the antagonist group, but the difference was not statistically significant. CONCLUSION. A fixed multi-dose GnRH antagonist protocol is feasible for patients who are poor responders on a long agonist protocol; however, our study failed to demonstrate an overall improvement in ovarian responsiveness. Clinical outcomes may be improved by developing more flexible antagonist regimens, an approach that requires further evaluation.
- Subjects
CORPUS luteum; MENSTRUAL cycle; LUTEAL phase; FERTILIZATION in vitro
- Publication
Human Reproduction, 2005, Vol 20, Issue 3, p616
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deh668