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- Title
Outcome of subsequent pregnancy after treatment for persistent gestational trophoblastic tumour.
- Authors
Matsui, Hideo; Iitsuka, Yoshinori; Suzuka, Kiyomi; Yamazawa, Koji; Seki, Katsuyoshi; Sekiya, Souei
- Abstract
<bold>Background: </bold>This study analysed subsequent pregnancy outcome in patients treated for persistent gestational trophoblastic tumour (GTT).<bold>Methods: </bold>Between 1974 and 1999, a total of 378 patients with GTT (83 patients with high-risk and 295 patients with low-risk GTT) were treated at Chiba University Hospital, Japan. Of these 378 patients, 363 (96.0%) achieved primary remission and 315 survivors have been followed at our hospital.<bold>Results: </bold>To date, 129 patients have had 243 subsequent conceptions. While pregnancy outcome was comparable with that of the general Japanese population, the incidence of repeat molar pregnancy (2.1%) was approximately seven times higher than that of the general population. During the mandatory HCG follow-up period of 1 year, 15 patients conceived within 6 months of completion of chemotherapy. The incidence of spontaneous abortion in these 15 patients was significantly higher than that in patients who conceived after a waiting period of >6 months (P = 0.0053).<bold>Conclusions: </bold>Patients treated for GTT may anticipate a normal future reproductive outcome, although it would be better to avoid pregnancy for at least 6 months after completion of chemotherapy.
- Subjects
ANTINEOPLASTIC agents; EVALUATION of medical care; PREGNANCY; MOLAR pregnancy; UTERINE tumors; DISEASE relapse; DISEASE incidence
- Publication
Human Reproduction, 2002, Vol 17, Issue 2, p469
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/17.2.469