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- Title
Synthesis, biological activities and molecular docking simulation of hydrazone scaffolds of carvacrol, thymol and eugenol.
- Authors
Rajput, Jamatsing; Bagul, Suresh; Bendre, Ratnamala
- Abstract
In present work, we report the synthesis of 12 new hydrazones and sulfonyl hydrazones linkage containing carvacrol, thymol and eugenol derivatives by simple condensation reactions. Synthesized derivatives have been characterized by H NMR, C NMR, LC-MS, and X-ray single crystallography techniques, and these derivatives were screened for anticancer testing by using sulforhodamine B assay and anti-oxidant testing by using DPPH assay. Docking studies of all the derivatives against the active site of human heme oxygenase-1 indicated that interaction with the maximum site of the amino acid residue of human heme oxygenase-1 was crucial for anti-oxidant activity. The results show that all derivatives possess interesting biological activities.
- Subjects
HYDRAZONES; AZO compounds; CARVACROL; CONDENSATION; HYDRAMETHYLNON
- Publication
Research on Chemical Intermediates, 2017, Vol 43, Issue 11, p6601
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-017-3007-3