We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.
- Authors
Bu, Guojun
- Abstract
The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the epsilon4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-beta peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors. Emerging knowledge of the contribution of APOE to the pathophysiology of AD presents new opportunities for AD therapy.
- Subjects
ALZHEIMER'S disease risk factors; APOLIPOPROTEIN E; GENETIC polymorphisms; LIPID metabolism; PATHOLOGICAL physiology
- Publication
Nature Reviews Neuroscience, 2009, Vol 10, Issue 5, p333
- ISSN
1471-003X
- Publication type
journal article
- DOI
10.1038/nrn2620