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- Title
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
- Authors
Nefzger, Christian M.; Jardé, Thierry; Srivastava, Akanksha; Schroeder, Jan; Rossello, Fernando J.; Horvay, Katja; Prasko, Mirsada; Paynter, Jacob M.; Chen, Joseph; Weng, Chen-Fang; Sun, Yu B. Y.; Liu, Xiaodong; Chan, Eva; Deshpande, Nikita; Chen, Xiaoli; Li, Y. Jinhua; Pflueger, Jahnvi; Engel, Rebekah M.; Knaupp, Anja S.; Tsyganov, Kirill
- Abstract
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
- Subjects
CELLULAR aging; STEM cells; REGENERATION (Biology); INTESTINES; TRANSCRIPTION factors
- Publication
NPJ Regenerative Medicine, 2022, Vol 7, Issue 1, p1
- ISSN
2057-3995
- Publication type
Article
- DOI
10.1038/s41536-022-00226-7