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- Title
Forkhead box proteins: tuning forks for transcriptional harmony.
- Authors
Lam, Eric W.-F.; Brosens, Jan J.; Gomes, Ana R.; Koo, Chuay-Yeng
- Abstract
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.
- Subjects
FORKHEAD transcription factors; GENETIC transcription; TISSUES; GENE expression; CANCER cells; DISEASE progression; DRUG resistance
- Publication
Nature Reviews Cancer, 2013, Vol 13, Issue 7, p482
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3539