We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protein kinase C and other diacylglycerol effectors in cancer.
- Authors
Griner, Erin M.; Kazanietz, Marcelo G.
- Abstract
Almost three decades after the discovery of protein kinase C (PKC), we still have only a partial understanding of how this family of serine/threonine kinases is involved in tumour promotion. PKC isozymes — effectors of diacylglycerol (DAG) and the main targets of phorbol-ester tumour promoters — have important roles in cell-cycle regulation, cellular survival, malignant transformation and apoptosis. How do PKC isozymes regulate these diverse cellular processes and what are their contributions to carcinogenesis? Moreover, what is the contribution of all phorbol-ester effectors, which include PKCs and small G-protein regulators? We now face the challenge of dissecting the relative contribution of each DAG signal to cancer progression.
- Subjects
PROTEIN kinase C; DIGLYCERIDES; PROTEIN kinases; PHORBOL esters; COCARCINOGENS; CELL cycle regulation; APOPTOSIS; CANCER prognosis
- Publication
Nature Reviews Cancer, 2007, Vol 7, Issue 4, p281
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc2110