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- Title
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.
- Authors
Bossen, Claudia; Murre, Caroline S; Chang, Aaron N; Mansson, Robert; Rodewald, Hans-Reimer; Murre, Cornelis
- Abstract
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B lineage development remains to be determined. Here we found that in lymphoid progenitor cells, the chromatin remodeler Brg1 specified the B cell fate. In committed pro-B cells, Brg1 regulated contraction of the locus encoding the immunoglobulin heavy chain (Igh) and controlled expression of the gene encoding the transcription factor c-Myc (Myc) to modulate the expression of genes encoding products that regulate ribosome biogenesis. In committed pro-B cells, Brg1 suppressed a pre-B lineage-specific pattern of gene expression. Finally, we found that Brg1 acted mechanistically to establish B cell fate and modulate cell growth by facilitating access of lineage-specific transcription factors to enhancer repertoires.
- Subjects
B cells; CHROMATIN-remodeling complexes; GROWTH factors; GENETIC transcription regulation; PROGENITOR cells; GENE expression
- Publication
Nature Immunology, 2015, Vol 16, Issue 7, p775
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.3170