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- Title
Application of Nano-Particulate Drug Delivery Systems to Deliver Therapeutic Agents into Cancer Cells.
- Authors
Kadhim, Weam A.; Alfuraiji, Narjes; Hameed, Rana Majeed; Abdulzahra, Qasim Chyad
- Abstract
Cancer is a disorder where a group of cells grows uncontrollably, ignoring the physiological rules of cells division. Since its discovery (although the word cancer was not used)3000 BC, extraordinary research aims to uncover novel therapeutic strategies for combating it. Currently, over 60% of clinical trials over the globe focus on cancer. The type of cancer, site, and stage of progression are among the factors determining the treatment selection. Traditional treatment approaches include chemotherapy, surgery, radiation, and radiation-based surgical knives. Side effects associated with traditional therapy highlights the need for novel cancer treatment. Nanotechnology is widely investigated and utilized to treat cancer, where nanoparticles have had a vital role in delivering anticancer medication. Nanoparticle-based drug delivery provides several advantages over conventional drug delivery, including enhanced biocompatibility, stability, permeability, and retention effect, as well as precision targeting. It has also been proven to tackle the resistance to anticancer drugs by targeting the underlying mechanism (drug efflux transporters overexpression, imperfect apoptotic pathways, and a hypoxic environment), enhancing multidrug resistance reversal. Moreover, nanoparticles' role in immunotherapy is undergoing investigation due to their essential role in treating cancer. The current article highlights the role of NP in delivering a chemotherapeutic medication, targeted treatment, and the mechanisms of targeting.
- Subjects
DRUG delivery systems; CANCER cells; ANTINEOPLASTIC agents; DRUG resistance; MULTIDRUG resistance; IMMUNOTHERAPY
- Publication
Kerbala Jorunal of Medicine, 2021, Vol 14, Issue 2, p2496
- ISSN
1990-5483
- Publication type
Article