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- Title
Perineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome.
- Authors
Laske, Roman D.; Scholz, Irene; Ikenberg, Kristian; Meerwein, Christian; Vital, Domenic G.; Studer, Gabriela; Rössle, Matthias; Huber, Gerhard F.
- Abstract
Objectives/Hypothesis To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage. Study Design Retrospective case-control study with clinicopathological analysis. Methods Seventeen patients who received primary surgical treatment for SCC of the oral cavity with PNI were matched to a control group. In a histologic review, PNI was classified into subtypes according to an adapted Liebig classification. The term type A was used to describe tumor invasion into the nerve, whereas type B was used to describe circumferential growth around the nerve. Clinical charts were reviewed, and a Kaplan-Meier survival analysis was performed. Results The recurrence-free survival rates were 47.1% versus 80.4% (PNI vs. matched control group, P < 0.05), 60.0% versus 94.1% (PNI in stage I and II disease vs. matched control group, P < 0.05) and 41.7% versus 73.5% (PNI in stage III and IV disease vs. matched control group, P < 0.05). In most cases (n = 9) of PNI, both histologic subtypes (type A and type B) were present. Five cases exclusively showed type A, and three cases exclusively showed type B. Conclusions Perineural invasion in early disease oral carcinoma has a particularly high impact on survival. Both histologic subtypes showed a significantly worse recurrence-free survival rate when compared to the control group. Level of Evidence 3.
- Subjects
CANCER invasiveness; DENTAL pulp cavities; SQUAMOUS cell carcinoma; METASTASIS; TUMOR growth; HISTOLOGY
- Publication
Laryngoscope Investigative Otolaryngology, 2016, Vol 1, Issue 1, p13
- ISSN
2378-8038
- Publication type
Article
- DOI
10.1002/lio2.4