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- Title
Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.
- Authors
Arcos-Sacramento, Víctor Gildardo; Sampieri, Clara Luz; Hugo Sandoval-Lozano, Víctor; Arturo Orozco-Ortega, Rubén; Acuña-Hernández, Mariel Alejandra; Morales-Romero, Jaime; Hernández-Hernández, Magda Elena; Rodríguez-Hernández, Arturo
- Abstract
Background. Chronic kidney disease is one of the most common complications of type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular morbidity and mortality. Matrix metalloproteinase (MMP) activity has been proposed as useful biomarker for diabetic renal and vascular complications. Methods. A cross-sectional study was conducted among T2DM patients who attended a public secondary hospital in Mexico. We performed clinical, biochemical, and microbiological assessments, as well chronic kidney disease diagnosis according to the KDIGO guideline. Urinary MMP-9 was quantified by ELISA and adjusted using urinary creatinine (UCr). Results. A total of 111 patients were included. Most participants were women (66%). Mean age was 61 ± 10 years and median T2DM duration was estimated at 11 years. Through multivariate analysis, MMP-9/UCr was found to be associated with albumin concentration and albumin to creatinine ratio. Discussion. Validation of non-invasive biomarkers of chronic kidney disease among T2DM patients is necessary. Here, we demonstrate MMP-9/UCr as a potential biomarker of albumin concentration and albumin to creatinine ratio in Mexican patients with T2DM.
- Subjects
MEXICO; TYPE 2 diabetes; MEXICANS; DIABETIC angiopathies; CHRONIC kidney failure; ALBUMINS; KIDNEY disease diagnosis
- Publication
PeerJ, 2020, p1
- ISSN
2167-8359
- Publication type
Article
- DOI
10.7717/peerj.10474