We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
P2: The possible involvement of a wide range of viruses in sporadic breast cancer in a Moroccan population.
- Authors
ElAmrani, Amal; Gheit, Tarik; Benhassou, Mustapha; McKay-Chopin, Sandrine; Attaleb, Mohamed; Sahraoui, Souha; Ennaji, Moulay Mustapha; Corbex, Marilys; Tommasino, Massimo; Khyatti, Meriem
- Abstract
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for 23% of total new cancer cases and 14% of total cancer deaths. In Morocco, BC is the most common cancer affecting women, with an incidence rate of 17.1/100.000 residents. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is growing each year. Among them, viruses play a significant role. This is the first study that explored the presence of a wide range of viruses in in 112 patients with BC using Luminex technology. Interestingly, the beta-HPV types were found in 9.1% of subject and gamma-HPV types in 5.7% of cases, while the low-risk and probable/high risk HPV types were present in 6.8% and 4.54% of cases, respectively. High risk mucosal HPV types 16 and 18 were not detected in our samples, but other probable/high risk types were detected (HPV 51, 52, 58, 59 and 66). The low risk mucosal HPV type 11 was the most prevalent type (13.3%). Noteworthy, EBV have been found (EBV1) in a total of 16 patients, twelve of which were carrying the EBV type 1 and four the EBV type 2. In addition, EBV was absent in normal breast samples. MCV is the third most detected virus which was found in 14.47% of our samples but unlike EBV, the virus was also found in normal breast tissues. On the other hand, the BKV, KIV, JCV, WUV, SV40, TSV, HPyV9, HSV1, MMTV were globally absent or insignificant, while HPyV6 was found in only two cases and HPyV7, CMV and HSV2 found in one sample each. However, despite the presence of some viruses in breast samples further work needs to be done to clarify the role and the risk assessment of this virus in human BC.
- Subjects
MOROCCO; BREAST cancer; ONCOGENIC viruses; WOMEN
- Publication
Clinical Cancer Investigation Journal, 2015, Vol 4, Issue S1, pS22
- ISSN
2278-1668
- Publication type
Abstract