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- Title
Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium.
- Authors
Rwere, Freeborn; Yu, Xuan; Chen, Che-Hong; Gross, Eric R.
- Abstract
Although much attention focuses on ALDH2 and the ALDH2*2 genetic variant regarding aldehyde metabolism, this enzyme is also only one of 19 enzymes within the aldehyde dehydrogenase family. Aldehyde Exposure from Alcohol When consuming alcohol, the key enzyme responsible for converting acetaldehyde to acetic acid is aldehyde dehydrogenase 2 (ALDH2). In another study, Shimonosono et al. reported that acetaldehyde is associated with alcohol-induced squamous cell carcinoma, suggesting ALDH2-dependent acetaldehyde metabolism prevents cancers associated with alcohol consumption [[14]]. As discussed below, the body of work for this Special Issue identifies the continued need to examine aldehyde toxicity and metabolism directly caused by alcohol consumption in addition to aldehydes generated from sources other than alcohol.
- Subjects
DNA adducts; ACETALDEHYDE; ALDEHYDES; CELL death
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 6, p763
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12060763