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- Title
COMPARATIVE EFFECT OF ZOLEDRONIC ACID VERSUS DENOSUMAB ON SERUM SCLEROSTIN AND DICKKOPF-1 LEVELS OF NAÏVE POSTMENOPAUSAL WOMEN WITH LOW BONE MASS: A RANDOMIZED, HEAD-TO-HEAD CLINICAL TRIAL.
- Authors
ANASTASILAKIS, Athanasios D.; POLYZOS, Stergios A.; GKIOMISI, Athina; BISBINAS, Ilias; DELAROUDIS, Sideris; GEROU, Spyridon; MAKRAS, Polyzois
- Abstract
PURPOSE: Decreased bone formation, due to the coupling effect, limits bone mass increases following antiresorptive treatment. We aimed to compare the effects of two potent antiresorptives with different mechanism of action on serum levels of Wnt antagonists sclerostin and dickkopf-1 (Dkk-1). MATERIALS AND METHODS: Naïve postmenopausal women with low bone mass were assigned to zoledronic acid infusion (n=45) or denosumab injection (n=46). Main outcome measurements were serum sclerostin and Dkk-1 levels. Secondary measurements included serum osteoprotegerin (OPG), receptor activator of nuclear factor kappaB ligand (RANKL), (procollagen type 1 N-terminal propeptide [P1NP] and C-terminal cross- linking telopeptide of type 1 collagen [CTx]). RESULTS: Serum sclerostin levels decreased significantly in the zoledronic acid (p<0.001), whereas increased in the denosumab group (p=0.003). Dkk-1 levels decreased significantly in the zoledronic acid group (p=0.006), but did not change in the denosumab group (p=0.402). Serum OPG remained essentially unchanged in both groups. Bone markers (P1NP and CTx) decreased in both groups (all p<0.001) and CTx and P1NP were significantly lower at month 3 in the denosumab than in the zoledronic acid group (p<0.001 and p=0.016, respectively). CONCLUSIONS: Despite the similar effect on bone turnover, zolendronic acid and denosumab exert an opposite effect on Wnt signaling: the first decreases serum levels of both sclerostin and Dkk-1 while the second increases sclerostin and does not affect Dkk-1.
- Publication
Balkan Military Medical Review, 2013, Vol 16, p173
- ISSN
1107-6275
- Publication type
Article