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- Title
Effect of Memantine on Prolonging Safe Driving in Early AD: a Pilot Study.
- Authors
Holland, Peter J.; Tappen, Ruth M.; Newman, David O.; Freeman-Costin, Katherine C.; Fisher, Lori J.
- Abstract
Background To determine the feasibility of conducting an RCT on the potential effectiveness of memantine hydrochloride in prolonging safe driving in mild AD. Methods A placebo-controlled, double blind randomized trial was conducted. Forty-three individuals ≥60 with mild AD met screening criteria and were randomized. Driving ability was measured by a standardized on-road driving test. Outcomes were driving capacity at 6 and 12 months and completion of the 12-month intervention. Results Of 43 participants randomized, 59% of the memantine group and 52% of the placebo group completed the on-road test at 12 months (p = .66). All 13 memantine group participants maintained their driving status at 12 months, whereas only 8 of the 11 placebo group participants did (p = .040, OR = 4.45). Conclusions Results provide the framework for designing a rigorous multisite clinical trial of memantine effect on maintaining driving capacity in mild AD.
- Subjects
SAFETY; PILOT projects; AUTOMOBILE drivers' tests; MEMANTINE; ALZHEIMER'S disease; HEALTH outcome assessment; RANDOMIZED controlled trials; NEUROPSYCHOLOGICAL tests; AUTOMOBILE driving; BLIND experiment; PHARMACODYNAMICS
- Publication
Canadian Geriatrics Journal, 2021, Vol 24, Issue 4, p292
- ISSN
1925-8348
- Publication type
Article
- DOI
10.5770/cgj.24.540