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- Title
Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study.
- Authors
Ford, Jennifer; Hategan, Ana; Bourgeois, James A.; Tisi, Daniel K.; Xiong, Glen L.
- Abstract
Background As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. Methods Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked. Results Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male. Conclusions Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium.
- Subjects
ONTARIO; CALCIUM metabolism; RISK of delirium; MEDICAL screening; ACADEMIC medical centers; ANALYSIS of covariance; BIOMARKERS; COGNITION; STATISTICAL correlation; CLINICAL pathology; MEDICAL cooperation; REFERENCE values; RESEARCH; SEX distribution; VITAMIN D deficiency; MULTIPLE regression analysis; DISCHARGE planning; CROSS-sectional method; RETROSPECTIVE studies; DESCRIPTIVE statistics
- Publication
Canadian Geriatrics Journal, 2013, Vol 16, Issue 4, p186
- ISSN
1925-8348
- Publication type
Article
- DOI
10.5770/cgj.16.79