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- Title
UMA ANÁLISE DOS PRINCIPAIS DIAGNÓSTICOS DE SARSCOV- 2 DISPONÍVEIS NO BRASIL: UMA REVISÃO DE LITERATURA.
- Authors
Hirt da Silva, Mayra Deyse; Cristina Ferrari, Idalina; Aparecida dos Santos Pires, Maria; Alves da Silva, Éderson Rodrigo; Kakuta, Elaine; Eduardo de Barros, Marcio; Juliano Negrão, Fábio
- Abstract
Introduction: With the emergence of SARS-CoV-2, a large number of diagnostic tools were made available. In this context, the lack of vaccine, treatment and the large number of severe cases and death, allowed the emergency approval of several tests, which still require population studies for their definitive registration. Objective: To carry out a literature review to evaluate the diagnostic methodologies available in Brazil, according to the local health reality, exploring the epidemiological moment, the complexity of the test and the purpose of its application. Methodology: This is a bibliographic, descriptive study of the literature review type. The following scientific databases were used for searches: PUBMED, MEDLINE, LILACS AND COCHRANE LIBRARY, through selected descriptors on the DECS platform. Results: The scenario of several tests, based on different methodologies, such as tests based on viral RNA, on detection of viral antigens or antibodies, associated with knowledge of the natural history of the virus, allows a critical analysis of the best diagnosis according to the patient's clinical, epidemiological, diagnostic objective and assay accuracy. Currently, there is a change in the immune pattern of the population and the description of types and subtypes of SARS-CoV-2 with genetic changes, which can lead to changes in diagnostic accuracy or the re-emergence in outbreaks of severe disease. Conclusion: The evolutionary path of the natural history of Covid-19 is still uncertain and diagnostic assays are at different stages of development, validation and production and each type of test has its own distinct advantages and disadvantages inherent in the technology platform of origin and a combination of types of tests used at different times can be useful for the clinical management of patients and in the control of the SARS-CoV-2 pandemic.
- Publication
Arquivos de Ciências da Saúde da UNIPAR, 2023, Vol 27, Issue 3, p1322
- ISSN
1415-076X
- Publication type
Article
- DOI
10.25110/arqsaude.v27i3.2023-017