We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathogenesis‐directed treatment of linear porokeratosis with topical cholesterol‐lovastatin.
- Authors
Maredia, Hasina; Hand, Jennifer L.; Tollefson, Megha M.
- Abstract
A 2‐year‐old boy presented with an extensive, asymptomatic, photosensitive eruption refractory to topical steroids and tretinoin; examination and biopsies were consistent with generalized linear porokeratosis involving the face, limbs, and trunk. Treatment with topical cholesterol‐lovastatin was initiated, and it successfully improved early erythematous lesions. Whole exome sequencing that targeted mevalonate pathway genes crucial in cholesterol synthesis later revealed a pathogenic, paternally inherited, porokeratosis‐associated MVD, c.70+5 G>A, mutation. Topical cholesterol‐lovastatin is a safe and effective empiric treatment for porokeratosis when used in the early, erythematous phase, and its success is likely mediated through its role in targeting mevalonate pathway mutations.
- Subjects
TRETINOIN; CHOLESTEROL; GENETIC mutation; REFRACTORY materials; OINTMENTS; ACNEIFORM eruptions
- Publication
Pediatric Dermatology, 2024, Vol 41, Issue 2, p296
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.15427