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- Title
The relationship between αB-crystallin and neurofibrillary tangles in Alzheimer's disease.
- Authors
Mao, J. J.; Katayama, S.; Watanabe, C.; Harada, Y.; Noda, K.; Yamamura, Y.; Nakamura, S.
- Abstract
αB-crystallin is known as a small heat shock protein with a cytoprotective function. This study was undertaken to investigate the relationship between αB-crystallin and changes seen in Alzheimer's disease. The distribution and immunohistochemical characteristics of αB-crystallin positive neurones in the cerebral cortices of 4 patients with Alzheimer's disease were examined. αB-crystallin positive neurones were mainly distributed in the limbic and paralimbic regions, namely parahippocampal gyrus, fusiform gyrus, cingulate cortex, middle and superior frontal gyrus, and insular cortex, which corresponded to commonly affected regions in Alzheimer's disease. Moreover, such neurones were present predominantly in the III or V layer of the cerebral cortex. The number of αB-crystallin positive neurones increased in parallel with the neuronal loss. Logistic regression analysis revealed a significant relation between the density of αB-crystallin positive neurones and that of extracellular neurofibrillary tangles (NFTs), with a correlation coefficient (r) of 0.57 and P < 0.0001 in 14 regions of the cerebral cortex. In contrast, the relation was not statistically significant between the density of αB-crystallin positive neurones and that of classical senile plaques, diffuse plaques or intracellular NFTs. Modified Gallyas–Braak (GB) staining on αB-crystallin positive neurone demonstrated several patterns of the structures: faint GB positive structures in the swollen perikaryon with straight neurites, fine granules compressed and contorted into fuzzy bundles, intensely GB positive filamentous structures together with fine granules and very intensely GB positive ring-like NFTs in a swollen perikaryon with curved neurites. In positive neurones, the density of ring-like NFTs correlated with that of atrophic perikaryon, or bent neurites and a decrease in the immuoreactivity of αB-crystallin. These data suggest that a close relationship exists between the appearance of αB-crystallin in neurones, extracellular NFTs, and neurofibrillary formation in αB-crystallin positive neurones in Alzheimer brain.
- Subjects
ALZHEIMER'S disease; CEREBRAL cortex; HEAT shock proteins
- Publication
Neuropathology & Applied Neurobiology, 2001, Vol 27, Issue 3, p180
- ISSN
0305-1846
- Publication type
Article
- DOI
10.1046/j.1365-2990.2001.00310.x