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- Title
A SHORT REVIEW ON "A NOVEL APPROACH IN ORAL FAST DISSOLVING DRUG DELIVERY SYSTEM".
- Authors
Tiwari Bhupendra, R.; Rane Bhushan, R.; Gujrathi Nayan, A.; Bakliwal Sunil, R.; Tiwari Pranav, R.; Pawar, S. P.
- Abstract
Fast dissolving tablets are disintegrating or dissolve quickly in the saliva without water. Some tablets are designed to dissolve in saliva extremely fast, within a few seconds. Others containing agents to enhance the rate of tablet disintegration in the oral cavity and more appropriately termed as fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva within few seconds. Fast or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Such formulations provide an opportunity for product line extension in the many elderly persons will have difficulties in taking conventional oral dosage forms (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphagia. Swallowing problems also are common in young individuals because of their underdeveloped muscular and nervous systems. Other groups that may experience problems using conventional oral dosage forms include the mentally ill, the developmentally disabled, and patients who are uncooperative, on reduced liquid-intake plans, or are nauseated. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult.
- Subjects
DRUG tablets; DRUG delivery systems; PHARMACEUTICAL research; SOLID dosage forms; SALIVARY glands
- Publication
Pharma Science Monitor, 2012, Vol 3, Issue 4, p3080
- ISSN
0976-9242
- Publication type
Article