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- Title
Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease.
- Authors
Rossi, Marianna Nicoletta; Fiorucci, Cristian; Mariottini, Paolo; Cervelli, Manuela
- Abstract
Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and pathology. In particular, PA have been involved in the regulation of cell homeostasis and proliferation participating in the control of fundamental processes like DNA transcription, RNA translation, protein hypusination, autophagy and modulation of ion channels. Indeed, their dysregulation has been associated to inflammation, oxidative stress, neurodegeneration and cancer progression. Accordingly, PA intracellular levels, derived from the balance between uptake, biosynthesis, and catabolism, need to be tightly regulated. Among the mechanisms that fine-tune PA metabolic enzymes, emerging findings highlight the importance of noncoding RNAs (ncRNAs). Among the ncRNAs, microRNA, long noncoding RNA and circRNA are the most studied as regulators of gene expression and mRNA metabolism and their alteration have been frequently reported in pathological conditions, such as cancer progression and brain diseases. In this review, we will discuss the role of ncRNAs in the regulation of PA genes, with a particular emphasis on the changes of this modulation observed in health disorders.
- Subjects
NON-coding RNA; RNA metabolism; ION channels; LINCRNA; GENE expression; METABOLISM; CELLULAR control mechanisms
- Publication
Cell & Bioscience, 2024, Vol 14, Issue 1, p1
- ISSN
2045-3701
- Publication type
Article
- DOI
10.1186/s13578-024-01235-3